Resource Type

Journal Article 189

Conference Videos 3

Year

2023 22

2022 26

2021 21

2020 15

2019 10

2018 8

2017 18

2016 13

2015 13

2014 8

2013 2

2012 5

2011 7

2010 5

2009 2

2008 3

2007 2

2006 3

2003 1

2001 1

open ︾

Keywords

COVID-19 5

animal models 3

Control 2

SARS-CoV-2 2

artificial intelligence 2

circular economy 2

development strategies 2

development strategy 2

food security 2

green development 2

quality 2

wastewater treatment 2

14th Five-Year Plan 1

2035 1

2050 1

3-DOF translational PKM 1

4S integration 1

Chlorella sp. HQ 1

Cronobacter sakazakii 1

open ︾

Search scope:

排序： Display mode:

Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 401-413 doi: 10.1007/s11684-011-0161-7

Abstract: In this paper, we review the current choices of cell source and strategies on directing the osteogenicThe preclinical animal models for bone regeneration and the key translational points to clinical successWe propose comprehensive strategies based on stem cell and tissue engineering researches, allowing for

Keywords： bone regeneration     animal models     translational strategies     oral and maxillofacial region    

HTML PDF Collect

Error analysis and optimization of a 3-degree of freedom translational Parallel Kinematic Machine

S. SHANKAR GANESH,A. B. KOTESWARA RAO

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 2,   Pages 120-129 doi: 10.1007/s11465-014-0300-3

Abstract:

In this paper, error modeling and analysis of a typical 3-degree of freedom translational ParallelThis mechanism provides translational motion along the Cartesian X-, Y- and 

Keywords： translational Parallel Kinematic Machine     error modeling     global error transformation index    

HTML PDF Collect

Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)

ZHAI Wenjie, LIU Changxiong, LIANG Yingchun

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 4,   Pages 441-448 doi: 10.1007/s11465-008-0074-6

Abstract: a wafer along a circular path without rotation, we developed a polishing technique called circular-translational-moving

Keywords： numerical analysis     practical CTMP     circular-translational-moving polishing     CTMP     different    

HTML PDF Collect

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

HTML PDF Collect

Stiffness of a 3-degree of freedom translational parallel kinematic machine

S. SHANKAR GANESH,A.B. KOTESWARA RAO

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 3,   Pages 233-241 doi: 10.1007/s11465-014-0312-z

Abstract:

In this paper, a typical 3-degree of freedom (3-DOF) translational parallel kinematic machineUsing the stiffness modeling the variations of minimum and maximum translational stiffness in the workspace

Keywords： 3-DOF translational PKM     inverse kinematics     stiffness modeling     translational stiffness    

HTML PDF Collect

Conceptual design of compliant translational joints for high-precision applications

Guangbo HAO,Haiyang LI,Xiuyun HE,Xianwen KONG

Frontiers of Mechanical Engineering 2014, Volume 9, Issue 4,   Pages 331-343 doi: 10.1007/s11465-014-0321-y

Abstract:

Compliant translational joints (CTJs) have been extensively used in precision engineering and microelectromechanical

Keywords： compliant mechanisms     translational joints     conceptual design     parallelogram     straight-line motion     combination    

HTML PDF Collect

Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 323-332 doi: 10.1007/s11684-011-0172-4

Abstract:
HTML PDF Collect

Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 3, doi: 10.1007/s11465-022-0695-1

Abstract: This study presents a family of novel translational parallel mechanisms (TPMs) with single-loop topologicalThe workspace of the 3-CRR (C denotes the cylindrical joint and R denotes the revolute joint) translational

Keywords： translational parallel mechanism     single loop     multiple driving system     workspace analysis     singularity    

HTML PDF Collect

Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 333-335 doi: 10.1007/s11684-011-0166-2

Abstract: medical needs but despite its considerable impetus, faces numerous challenges including support for translationalexamine the challenges confronting cell therapy research including the limited funding available for translational

Keywords： stem cells     clinical trials     funding     animal models     standardization     common definitions    

HTML PDF Collect

Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine

Jisheng Han, Cailian Cui, Liuzhen Wu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 141-150 doi: 10.1007/s11684-011-0136-8

Abstract: use of acupuncture-related technique for the treatment of opiate addiction from the perspective of translational

Keywords： morphine     dependence     withdrawal     addiction     dynorphins     acupuncture     electroacupuncture     transcutaneous electrical acupoint stimulation (TEAS)     enkephalins     endorphins    

HTML PDF Collect

Translational research on novel drug-eluting stents in percutaneous coronary intervention

Yaling Han, Kai Xu, Chenghui Yan

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 395-400 doi: 10.1007/s11684-011-0167-1

Abstract: Translational research plays a very important role in experiments which determine the safety and efficacyThe present review focuses on translational research of novel DES, including drug discovery, creation

Keywords： translational research     drug-eluting stents     percutaneous coronary intervention    

HTML PDF Collect

improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled trial     DNA N6-methyladenine modification    

HTML PDF Collect

Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 351-355 doi: 10.1007/s11684-010-0320-2

HTML PDF Collect

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53 mutations and extremely poor prognosis. In a retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associated with p53 mutations (P = 0.037) and poor overall survival (OS) (P = 0.010). In a prospective DEciTabinE and Carboplatin in TNBC (DETECT) trial (NCT03295552), decitabine with carboplatin produced an objective response rate (ORR) of 42% in 12 patients with stage IV TNBC. Among the 9 trialed patients with available TP53 sequencing results, the 6 patients with p53 mutations had higher ORR (3/6 vs. 0/3) and better OS (16.0 vs. 4.0 months) than the patients with wild-type p53. In a mechanistic study, isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53. In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and the most responsive patient with TNBC. Our integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

HTML PDF Collect

Translational initiatives in thrombolytic therapy

Melvin E. Klegerman

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 1-19 doi: 10.1007/s11684-017-0497-8

Abstract: strategy to ameliorate this adverse effect is nanoparticulate encapsulation or complexation, and many strategies

Keywords： thrombolytics     nanomedicine     plasminogen activators    

HTML PDF Collect

Title Author Date Type Operation

Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region

Zhiyuan Zhang

Journal Article

Error analysis and optimization of a 3-degree of freedom translational Parallel Kinematic Machine

S. SHANKAR GANESH,A. B. KOTESWARA RAO

Journal Article

Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)

ZHAI Wenjie, LIU Changxiong, LIANG Yingchun

Journal Article

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

Stiffness of a 3-degree of freedom translational parallel kinematic machine

S. SHANKAR GANESH,A.B. KOTESWARA RAO

Journal Article

Conceptual design of compliant translational joints for high-precision applications

Guangbo HAO,Haiyang LI,Xiuyun HE,Xianwen KONG

Journal Article

Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

Journal Article

Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures

Journal Article

Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

Journal Article

Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine

Jisheng Han, Cailian Cui, Liuzhen Wu

Journal Article

Translational research on novel drug-eluting stents in percutaneous coronary intervention

Yaling Han, Kai Xu, Chenghui Yan

Journal Article

improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational

Journal Article

Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational

Journal Article

Translational initiatives in thrombolytic therapy

Melvin E. Klegerman

Journal Article